A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
نویسندگان
چکیده
The authors’ affiliations are listed in the Appendix. Address reprint requests to Dr. Oxman at the Shingles Prevention Study (Mail code 111F-1), VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA 92161, or at mnoxman@ucsd. edu. *Other members of the Shingles Prevention Study Group are listed in the Appendix. N Engl J Med 2005;352:2271-84. Copyright © 2005 Massachusetts Medical Society. background The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella– zoster virus (VZV). We tested the hypothesis that vaccination against VZV would decrease the incidence, severity, or both of herpes zoster and postherpetic neuralgia among older adults.
منابع مشابه
A vaccine to prevent herpes zoster and post-herpetic neuralgia in older adults.
BACKGROUND The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella-zoster virus (VZV). We tested the hypothesis that vaccination against VZV would decrease the incidence, severity, or both of herpes zoster and postherpetic neuralgia among older adults. METHODS We enrolled 38,546 a...
متن کاملCost-effectiveness of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.
BACKGROUND A vaccine to prevent herpes zoster was recently approved by the United States Food and Drug Administration. We sought to determine the cost-effectiveness of this vaccine for different age groups. METHODS We constructed a cost-effectiveness model, based on the Shingles Prevention Study, to compare varicella zoster vaccination with usual care for healthy adults aged >60 years. Outcom...
متن کاملCost Effectiveness Analysis of A Vaccine To Prevent Herpes Zoster and Postherpetic Neuralgia in Italy.
Background. Herpes zoster (HZ), or shingles, is a painful disease that results from reactivation of the varicella zoster virus (VZV) which has remained latent in sensory ganglia following primary infection i.e. varicella (VZV), a virus commonly acquired in childhood (chickenpox) [1]. The most common complication is post-herpetic neuralgia (PHN), a severe pain that can persist for months [2]. HZ...
متن کاملVaccination against Herpes Zoster and Postherpetic Neuralgia.
BACKGROUND Herpes zoster (HZ) and postherpetic neuralgia (PHN) cause significant morbidity in older adults. The incidence and severity of HZ and PHN increase with age in association with an age-related decline in varicella-zoster virus (VZV)-specific cell-mediated immunity (VZV-CMI). VZV vaccines can boost VZV-CMI. Therefore, we tested the hypothesis that VZV vaccination would protect older adu...
متن کاملHerpes Zoster and Postherpetic Neuralgia: Prevention and Management.
Herpes zoster, or shingles, is caused by reactivation of varicella zoster virus, which causes chickenpox. There are an estimated 1 million cases in the Unites States annually, with an individual lifetime risk of 30%. Patients with conditions that decrease cell-mediated immunity are 20 to 100 times more likely to develop herpes zoster. Patients may present with malaise, headache, low-grade fever...
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تاریخ انتشار 2005